Hair loss drugs such as Dutasteride and Finasteride were primarily used to treat prostate adenoma. There is no official analogue for the treatment of baldness. But this does not prevent the use of both drugs to stop hair loss.
Dutasteride and Finasteride are inhibitors of the enzyme 5-alpha reductase. Reductase inhibitors work by preventing the conversion of testosterone to the more androgenic component DHT (dihydrotestosterone). DHT affects a number of disorders in men, including male-pattern hair loss and the development of benign prostatic hyperplasia. Despite the fact that Dutasteride is similar in structure and action to Finasteride, it differs from the first generation reductase inhibitor in its tissue selectivity. Finasteride inhibits the type 2 isoenzyme 5-alpha reductase, which is located mainly in the scalp and prostate gland. Dutasteride does not act specifically, but inhibits both type 1 and type 2 reductases. As such, it inhibits DHT conversion in all tissues, including the scalp, liver, prostate, and skin. Because of this, it also lowers systemic DHT levels much more effectively than Finasteride.
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